Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation
نویسندگان
چکیده
Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
منابع مشابه
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عنوان ژورنال:
دوره 58 شماره
صفحات -
تاریخ انتشار 2015